Structural organization of MYCN amplicons of neuroblastoma tumors, xenografts, and cell lines characterized by the sequences encompassing the MYCN amplicons in a human neuroblastoma cell line.

Abstract excerpt

We characterized differences in the structural organization of the MYCN amplicons of a number of neuroblastomas by analyzing 8 contigs spanning 330 kb cloned from the MYCN amplicon of a neuroblastoma cell line. Some regions were amplified in almost all specimens, the conserved regions (CRs), and...

Topics

• Alleles
• Animals
• Blotting, Southern
• Cell Line
• Gene Amplification
• Gene Rearrangement
• Genes, myc
• Humans
• Mice
• Mice, Nude
• Neuroblastoma
• Transplantation, Heterologous