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Article

Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification.

PloS one - 29 Aug 2008

Lundberg Gisela, Rosengren Anders H, Håkanson Ulf, Stewénius Henrik, Jin Yuesheng, Stewénius Ylva, Påhlman Sven, Gisselsson David

Abstract excerpt

BACKGROUND: Amplification of the oncogene MYCN in double minutes (DMs) is a common finding in neuroblastoma (NB). Because DMs lack centromeric sequences it has been unclear how NB cells retain and amplify extrachromosomal MYCN copies during tumour development. PRINCIPAL FINDINGS: We show that MYCN-carrying DMs in NB cells translocate from the nuclear interior to the periphery of the condensing chromatin at...

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Source

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Identifiers

PMID: 18769732
DOI: 10.1371/journal.pone.0003099
PMCID: PMC2518122

Genes

MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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