Article
Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification.
PloS one - 29 Aug 2008
Lundberg Gisela, Rosengren Anders H, Håkanson Ulf, Stewénius Henrik, Jin Yuesheng, Stewénius Ylva, Påhlman Sven, Gisselsson David
Abstract excerpt
BACKGROUND: Amplification of the oncogene MYCN in double minutes (DMs) is a common finding in neuroblastoma (NB). Because DMs lack centromeric sequences it has been unclear how NB cells retain and amplify extrachromosomal MYCN copies during tumour development. PRINCIPAL FINDINGS: We show that MYCN-carrying DMs in NB cells translocate from the nuclear interior to the periphery of the condensing chromatin at...
Topics
- Cell Cycle
- Cell Line, Tumor
- Chromosome Segregation
- Gene Amplification
- Genes, myc
- Genetic Variation
- Humans
- In Situ Hybridization, Fluorescence
- Microscopy, Atomic Force
- Microscopy, Fluorescence
- Mitosis
- Mutation
- N-Myc Proto-Oncogene Protein