Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular epidemiology and urothelial cancer.

Journal of UOEH - 1 Sept 2007

Tsukino Hiromasa, Omori Hisamitsu, Kohshi Kiyotaka, Yamano Yuko, Katoh Takahiko

Abstract excerpt

Tobacco smoking is the main cause of human urothelial cancer. It has been suggested that genetic susceptibility may contribute to the risk, because only a small portion of smokers develops urothelial cancer. Tobacco smoke contains many carcinogens which are activated or detoxified by phase-I or phase-II enzymes. The concentration of the ultimate carcinogen, which will react with DNA, is determined by the rate of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Smoking
Share to Arylamine N-Acetyltransferase
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to Isoenzymes

Share to Sulfotransferases

Share to Urologic Neoplasms

Share to Urothelium

Source

Identifiers

PMID: 17900006
DOI: 10.7888/juoeh.29.265

Genes

GSTM1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular epidemiology and urothelial cancer.PMID 17900006Read ↗

Bladder cancer risk from the perspective of genetic polymorphisms in the carcinogen metabolizing enzymes.Semantic proximity Read ↗

Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer.Semantic proximity Read ↗

Gender-specific effects of NAT2 and GSTM1 in bladder cancer.Semantic proximity Read ↗

Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer.Semantic proximity Read ↗

Genetic polymorphism of N-acetyltransferase and glutathione S-transferase related to neoplasm of genitourinary system. Minireview.Semantic proximity Read ↗

Glutathione S-transferase (GST) M1, T1 and N-acetyltransferase 2 (NAT2) polymorphisms and urothelial cancer risk with tobacco smoking.Semantic proximity Read ↗

Smoking and polymorphisms in xenobiotic metabolism and DNA repair genes are additive risk factors affecting bladder cancer in Northern Tunisia.Semantic proximity Read ↗

Cancer and molecular biomarkers of phase 2.Semantic proximity Read ↗

Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese population.Semantic proximity Read ↗

Modulation of urinary mutagenicity by genetically determined carcinogen metabolism in smokers.Semantic proximity Read ↗

Do smoking and polymorphisms in xenobiotic metabolizing enzymes affect the histological stage and grade of bladder tumors?Semantic proximity Read ↗

A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.