Article
GSTM1 and NAT2 genotypes and urinary mutagens in coke oven workers.
Carcinogenesis - 1 Aug 1996
Gabbani G, Hou S M, Nardini B, Marchioro M, Lambert B, Clonfero E
Abstract excerpt
The influence of the metabolic genotypes GSTM1 and NAT2 on the urinary excretion of mutagens in 46 coke oven workers (27 of them smokers) was studied. Exposure to polycyclic aromatic hydrocarbons (PAH) was estimated from urinary 1-pyrenol levels, which varied from 0.23 to 5.59 micromol/mol creatinine. Fourteen urine samples (30.4%), all but one belonging to smokers, were positive for mutagenic activity (i.e. at...
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