Article
Association of nm23-H1 allelic deletions with distant metastases in colorectal carcinoma.
Lancet (London, England) - 21 Sept 1991
Cohn K H, Wang F S, Desoto-LaPaix F, Solomon W B, Patterson L G, Arnold M R, Weimar J, Feldman J G, Levy A T, Leone A
Abstract excerpt
A prospective study analysed the prognostic value of nm23-H1 allelic deletions in colorectal cancer. Of 21 patients with no evidence of distant metastases at initial operation, 11 showed nm23-H1 allelic deletions (including 1 homozygous deletion); 10 had no nm23-H1 deletions. After median follow-up of 25 months, distant metastases had developed in 8 of 11 (73%) patients with nm23-H1 deletions but in only 2 of 10...
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