Article
Mutation of the nm23 gene, loss of heterozygosity at the nm23 locus and K-ras mutation in ovarian carcinoma: correlation with tumour progression and nm23 gene expression.
British journal of cancer - 1 Sept 1995
Mandai M, Konishi I, Komatsu T, Mori T, Arao S, Nomura H, Kanda Y, Hiai H, Fukumoto M
Abstract excerpt
Alteration of expression levels of the nm23 genes has previously been correlated with metastatic status of ovarian epithelial carcinoma. To elucidate the relevance of the qualitative changes of the nm23 genes to progression of ovarian carcinoma and/or to nm23 expression levels of the tumour, 41 s...
Topics
- Adult
- Aged
- DNA Mutational Analysis
- DNA, Neoplasm
- Disease Progression
- Female
- Gene Deletion
- Gene Expression
- Genes, ras
- Heterozygote
- Humans
- Middle Aged
- Monomeric GTP-Binding Proteins
- Mutation
- NM23 Nucleoside Diphosphate Kinases