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Article

Distinct neurotrophic responses of axotomized motor neurons to BDNF and CNTF in adult rats.

Neuroreport - 24 Feb 1994

Chiu A Y, Chen E W, Loera S

Abstract excerpt

In adult mammals, transection of the hypoglossal nerve results in a dramatic loss of choline acetyltransferase (ChAT) in the hypoglossal motor neurons without affecting their cell number. This injury-induced reduction in ChAT is prevented when brain-derived neurotrophic factor (BDNF) is applied to the proximal end of the transected nerve. In contrast, application of ciliary neurotrophic factor (CNTF) has no such...

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Source

Identifiers

PMID: 8199339
DOI: 10.1097/00001756-199402000-00008

Genes

BDNF
CNTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Distinct neurotrophic responses of axotomized motor neurons to BDNF and CNTF in adult rats.PMID 8199339Read ↗

Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons.Semantic proximity Read ↗

Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons.Semantic proximity Read ↗

BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons.Semantic proximity Read ↗

The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons.Semantic proximity Read ↗

Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy.Semantic proximity Read ↗

Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons.Semantic proximity Read ↗

GDNF gene delivery to injured adult CNS motor neurons promotes axonal growth, expression of the trophic neuropeptide CGRP, and cellular protection.Semantic proximity Read ↗

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.Semantic proximity Read ↗

Corticospinal neurons respond differentially to neurotrophins and myelin-associated glycoprotein in vitro.Semantic proximity Read ↗

Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb FunctionSemantic proximity Read ↗

Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing.Semantic proximity Read ↗

Neurotrophin-4/5 maintains the cholinergic phenotype of axotomized septal neurons.Semantic proximity Read ↗

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