Article
Distinct neurotrophic responses of axotomized motor neurons to BDNF and CNTF in adult rats.
Neuroreport - 24 Feb 1994
Chiu A Y, Chen E W, Loera S
Abstract excerpt
In adult mammals, transection of the hypoglossal nerve results in a dramatic loss of choline acetyltransferase (ChAT) in the hypoglossal motor neurons without affecting their cell number. This injury-induced reduction in ChAT is prevented when brain-derived neurotrophic factor (BDNF) is applied to the proximal end of the transected nerve. In contrast, application of ciliary neurotrophic factor (CNTF) has no such...
Topics
- Animals
- Axons
- Brain-Derived Neurotrophic Factor
- Cell Death
- Choline O-Acetyltransferase
- Ciliary Neurotrophic Factor
- Female
- Hypoglossal Nerve
- Immunohistochemistry
- Motor Neurons
- Nerve Growth Factors