Article
The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons.
The European journal of neuroscience - 1 May 1993
Wong V, Arriaga R, Ip N Y, Lindsay R M
Abstract excerpt
Although developing motor neurons express low-affinity nerve growth factor (NGF) receptors, there is no known biological effect of NGF on developing or adult motor neurons. In this study, we found that, unlike NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4...
Topics
- Animals
- Brain-Derived Neurotrophic Factor
- Cell Differentiation
- Cells, Cultured
- Choline O-Acetyltransferase
- Ciliary Neurotrophic Factor
- Embryo, Mammalian
- Immunohistochemistry
- Motor Neurons
- Nerve Growth Factors
- Nerve Tissue Proteins
- Neurotensin
- Parasympathetic Nervous System
- Phenotype
- Phosphopyruvate Hydratase
- Rats
- Staining and Labeling