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Article

BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Feb 1995

Friedman B, Kleinfeld D, Ip N Y, Verge V M, Moulton R, Boland P, Zlotchenko E, Lindsay R M, Liu L

Abstract excerpt

Adult motor neurons, like their immature antecedents, express the mRNA for the signaling receptor for brain-derived neurotrophic factor (BDNF) and for neurotrophin-4/5 (NT-4/5). However, while both BDNF and NT-4/5 support the survival of axotomized developing spinal motor neurons in vitro or in vivo, it is not known whether these factors continue to influence spinal motor neurons in adulthood. The present study...

Topics

Animals
Axons
Brain-Derived Neurotrophic Factor
Denervation
Male
Motor Neurons
Nerve Crush
Nerve Growth Factors
Nerve Tissue Proteins
Phenotype
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Sprague-Dawley

Sciatic Nerve

Spinal Cord

Spinal Cord Injuries

Source

Open in PubMed Open full text

Identifiers

PMID: 7869082
PMCID: PMC6577802

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7869082-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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BDNF and NT-4/5 exert neurotrophic influences on injured adult spinal motor neurons.PMID 7869082Read ↗

Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons.Semantic proximity Read ↗

Distinct neurotrophic responses of axotomized motor neurons to BDNF and CNTF in adult rats.Semantic proximity Read ↗

Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons.Semantic proximity Read ↗

The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons.Semantic proximity Read ↗

Retrograde response in axotomized motoneurons: nitric oxide as a key player in triggering reversion toward a dedifferentiated phenotype.Semantic proximity Read ↗

Neurotrophism without neurotropism: BDNF promotes survival but not growth of lesioned corticospinal neurons.Semantic proximity Read ↗

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Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb FunctionSemantic proximity Read ↗

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p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.Semantic proximity Read ↗

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