Interaction between the acceptor end of tRNA and the T box stimulates antitermination in the Bacillus subtilis tyrS gene: a new role for the discriminator base.

Abstract excerpt

The Bacillus subtilis tyrS gene is a member of a group of gram-positive aminoacyl-tRNA synthetase and amino acid biosynthesis genes which are regulated by transcription antitermination. Each gene in the group is specifically induced by limitation for the appropriate amino acid. This response is mediated by interaction of the cognate tRNA with the mRNA leader region to promote formation of an antiterminator...

Topics

• Bacillus subtilis
• Base Sequence
• Gene Expression Regulation, Bacterial
• Models, Genetic
• Molecular Sequence Data
• Mutation
• RNA, Transfer, Tyr
• Regulatory Sequences, Nucleic Acid
• Suppression, Genetic
• Terminator Regions, Genetic