Autocrine hepatocyte growth factor/scatter factor-Met signaling induces transformation and the invasive/metastastic phenotype in C127 cells.

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Article

Autocrine hepatocyte growth factor/scatter factor-Met signaling induces transformation and the invasive/metastastic phenotype in C127 cells.

Oncogene - 15 Aug 1996

Jeffers M, Rong S, Anver M, Vande Woude G F

Abstract excerpt

Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. C127 is a non-tumorigenic mouse cell line which expresses negligible levels of HGF/SF and Met proteins. In the present report we have generated C127 cells which overexp...

Topics

Animals
Cell Line
Cell Transformation, Neoplastic
Female
Hepatocyte Growth Factor
Humans
Mice
Mice, Nude
Neoplasm Invasiveness
Neoplasm Metastasis
Phenotype
Proto-Oncogene Proteins c-met
Receptor Protein-Tyrosine Kinases
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 8761307

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8761307-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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