Article
Constitutively active RAS prolongs Cdc42 signalling, while MAPK signalling is attenuated during fission yeast mating.
PLoS genetics - 1 Apr 2026
Kelsall Emma J, Kimura Akatsuki, Vértesy Ábel, Straatman Kornelis R, Tariq Mishal, Gadea Raquel, Parmar Chandni, Schreiber Gabriele, Randhawa Shubhchintan, Ida Takashi Y, Dominguez Cyril, Klipp Edda, Tanaka Kayoko
Abstract excerpt
The small GTPase RAS is a signalling hub activating multiple pathways, which may respond differently to a constitutively active RAS mutation. We explored this issue in fission yeast, where RAS-mediated pheromone signalling (PS) activates two downstream pathways: the MAPKSpk1 and Cdc42 pathways. We observed that the yeast RAS mutation ras1.G17V, an equivalent of the mammalian ras.G12V oncogenic mutation, causes...
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