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Article

Mutational analysis of Saccharomyces cerevisiae ARF1.

The Journal of biological chemistry - 6 Jan 1995

Kahn R A, Clark J, Rulka C, Stearns T, Zhang C J, Randazzo P A, Terui T, Cavenagh M

Abstract excerpt

Wild type and eight point mutants of Saccharomyces cerevisiae ARF1 were expressed in yeast and bacteria to determine the roles of specific residues in in vivo and in vitro activities. Mutations at either Gly2 or Asp26 resulted in recessive loss of function. It was concluded that N-myristoylation is required for Arf action in cells but not for either nucleotide exchange or cofactor activities in vitro. Asp26...

Topics

ADP-Ribosylation Factor 1
ADP-Ribosylation Factors
Alleles
Amino Acid Sequence
Aspartic Acid
Cysteine
DNA Mutational Analysis
GTP-Binding Proteins
Genes, Dominant
Genes, Lethal
Guanosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Point Mutation

Protein Binding

Saccharomyces cerevisiae

Source

Identifiers

PMID: 7814365
DOI: 10.1074/jbc.270.1.143

Genes

ARF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7814365-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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