Article
Bone marrow transplantation demonstrates that carbonic anhydrase II deficiency limited to bone marrow-derived cells affects ammonium chloride tolerance in mice.
Biochemical medicine and metabolic biology - 1 Feb 1994
Biesecker L G, Erickson R P, Tashian R E
Abstract excerpt
Bone marrow transplantation (BMT) in mice was utilized to determine the relative importance of carbonic anhydrase II (CA II) deficiency in blood compared to kidney in the pathogenesis of the ammonium chloride intolerance observed in CA II-deficient mice. "Normal" BMT experiments utilized normal donors and CA II-deficient recipients (NL-->DEF), "reverse" BMT experiments utilized CA II-deficient donors and normal...
Topics
- Ammonium Chloride
- Animals
- Bone Marrow
- Bone Marrow Cells
- Bone Marrow Transplantation
- Carbonic Anhydrases
- Drug Tolerance
- Hydrogen-Ion Concentration
- Kidney
- Mice
- Mice, Inbred C57BL