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Article

Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.

Journal of virology - 1 Jun 1994

Jamieson B D, Aldrovandi G M, Planelles V, Jowett J B, Gao L, Bloch L M, Chen I S, Zack J A

Abstract excerpt

The role of human immunodeficiency virus type 1 (HIV-1) accessory genes in pathogenesis has remained unclear because of the lack of a suitable in vivo model. The most controversial of these genes is nef. We investigated the requirement for Nef for in vivo replication and pathogenicity of two isolates of HIV-1 (HIV-1JR-CSF and HIV-1NL4-3) in human fetal thymus and liver implants in severe combined immunodeficient...

Topics

Animals
Base Sequence
Cytopathogenic Effect, Viral
DNA, Viral
Genes, nef
HIV Infections
HIV-1
Humans
Mice
Mice, SCID
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

T-Lymphocyte Subsets

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 8189487
DOI: 10.1128/JVI.68.6.3478-3485.1994
PMCID: PMC236850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8189487-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.PMID 8189487Read ↗

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