Article
A gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons.
The Journal of biological chemistry - 13 May 1994
Hertzog P J, Hwang S Y, Holland K A, Tymms M J, Iannello R, Kola I
Abstract excerpt
The type I interferons (IFNs) are a family of multifunctional cytokines which includes the 15 IFN alpha subtypes and IFN beta. These IFNs compete for binding to cell surface receptors. However, murine cells transfected with a cDNA for a human IFN alpha receptor (IFNAR) developed an antiviral response only to human IFN alpha B, but not to human IFN alpha 2 nor -beta(1). In this study we show, using a panel of...
Topics
- 2',5'-Oligoadenylate Synthetase
- Animals
- Biological Factors
- CHO Cells
- Chromosome Mapping
- Chromosomes, Human, Pair 21
- Cricetinae
- Enzyme Induction
- Genetic Predisposition to Disease
- Humans