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Article

The induction of smooth muscle alpha actin in a transformed rat cell line suppresses malignant properties in vitro and in vivo.

Cancer letters - 3 Aug 1999

Okamoto-Inoue M, Kamada S, Kimura G, Taniguchi S

Abstract excerpt

A normal rat fibroblast 3Y1 cell line expresses smooth muscle a actin and the expression of alpha actin is suppressed in the transformant (SR-3Y1-2) induced by a Raus sarcoma virus. Gene transfer with smooth muscle alpha actin into the SR-3Y1-2 cell line reduced growth and invasiveness in vitro, as well as tumor growth and experimental lung metastasis depending on the expression of the alpha actin. These results...

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Identifiers

PMID: 10463773
DOI: 10.1016/s0304-3835(99)00150-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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