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Article

The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi.

Journal of cell science - 1 May 1997

Nothwehr S F, Hindes A E

Abstract excerpt

Genetic analysis of late Golgi membrane protein localization in Saccharomyces cerevisiae has uncovered a large number of genes (called GRD) that are required for retention of A-ALP, a model late Golgi membrane protein. Here we describe one of the GRD genes, VPSS/GRD2, that encodes a hydrophilic protein similar to human sorting nexin-1, a protein involved in trafficking of the epidermal growth factor receptor. In...

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Source

Identifiers

PMID: 9175702
DOI: 10.1242/jcs.110.9.1063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi.PMID 9175702Read ↗

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.Semantic proximity Read ↗

The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.Semantic proximity Read ↗

A novel immunodetection screen for vacuolar defects identifies a unique allele of VPS35 in S. cerevisiae.Semantic proximity Read ↗

Vps10p transport from the trans-Golgi network to the endosome is mediated by clathrin-coated vesicles.Semantic proximity Read ↗

Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment.Semantic proximity Read ↗

Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.Semantic proximity Read ↗

Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p.Semantic proximity Read ↗

The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment.Semantic proximity Read ↗

An essential subfamily of Drs2p-related P-type ATPases is required for protein trafficking between Golgi complex and endosomal/vacuolar system.Semantic proximity Read ↗

VPS21 controls entry of endocytosed and biosynthetic proteins into the yeast prevacuolar compartment.Semantic proximity Read ↗

The yeast VRG4 gene is required for normal Golgi functions and defines a new family of related genes.Semantic proximity Read ↗

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