The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi.

doi:10.1242/jcs.110.9.1063

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Article

The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi.

Journal of cell science - 1 May 1997

Nothwehr S F, Hindes A E

Abstract excerpt

Genetic analysis of late Golgi membrane protein localization in Saccharomyces cerevisiae has uncovered a large number of genes (called GRD) that are required for retention of A-ALP, a model late Golgi membrane protein. Here we describe one of the GRD genes, VPSS/GRD2, that encodes a hydrophilic protein similar to human sorting nexin-1, a protein involved in trafficking of the epidermal growth factor receptor. In...

Topics

Alkaline Phosphatase
Carrier Proteins
Cell Fractionation
Cloning, Molecular
Endosomes
ErbB Receptors
Fungal Proteins
Genes, Reporter
Golgi Apparatus
Humans
Intracellular Membranes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Receptors, Cell Surface

Recombinant Fusion Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 9175702
DOI: 10.1242/jcs.110.9.1063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9175702-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi.PMID 9175702Read ↗

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.Semantic proximity Read ↗

The VPS8 gene is required for localization and trafficking of the CPY sorting receptor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.Semantic proximity Read ↗

A novel immunodetection screen for vacuolar defects identifies a unique allele of VPS35 in S. cerevisiae.Semantic proximity Read ↗

Vps10p transport from the trans-Golgi network to the endosome is mediated by clathrin-coated vesicles.Semantic proximity Read ↗

Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment.Semantic proximity Read ↗

Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.Semantic proximity Read ↗

Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p.Semantic proximity Read ↗

The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment.Semantic proximity Read ↗

An essential subfamily of Drs2p-related P-type ATPases is required for protein trafficking between Golgi complex and endosomal/vacuolar system.Semantic proximity Read ↗

VPS21 controls entry of endocytosed and biosynthetic proteins into the yeast prevacuolar compartment.Semantic proximity Read ↗

The yeast VRG4 gene is required for normal Golgi functions and defines a new family of related genes.Semantic proximity Read ↗

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