Experimental and clinical studies of cytokine gene-modified tumor cells.

doi:10.1089/hum.1994.5.2-153

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Article

Experimental and clinical studies of cytokine gene-modified tumor cells.

Human gene therapy - 1 Feb 1994

Tepper R I, Mulé J J

Abstract excerpt

Cytokines are key modulators of host immune and inflammatory responses. The expression of cytokine genes by tumor cells as a result of gene transfer has emerged as a novel strategy to augment in vivo host reactivity to various cancers. This review summarizes the knowledge obtained from experiment...

Topics

Animals
Antigens, Neoplasm
Clinical Trials as Topic
Clinical Trials, Phase I as Topic
Clinical Trials, Phase II as Topic
Cytokines
Cytotoxicity, Immunologic
Humans
Immunotherapy, Adoptive
Neoplasms
Neoplasms, Experimental
Phenotype
Recombinant Fusion Proteins
Remission Induction
Research Design
T-Lymphocytes, Cytotoxic

Source

Open in PubMed

Identifiers

PMID: 8186297
DOI: 10.1089/hum.1994.5.2-153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8186297-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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