Article
Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.
The cancer journal from Scientific American - 1 Jan 2000
Jaffee E M, Schutte M, Gossett J, Morsberger L A, Adler A J, Thomas M, Greten T F, Hruban R H, Yeo C J, Griffin C A
Abstract excerpt
Preclinical studies with murine tumor models have demonstrated that tumor cell vaccines engineered to secrete certain cytokines in a paracrine fashion elicit systemic immune responses capable of eliminating small amounts of established tumor. In particular, tumors that express the cytokine GM-CSF produce potent systemic antitumor immune responses against poorly immunogenic murine tumors. These results have...
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