Prolonged survival of rats with intracranial C6 gliomas by treatment with TGF-beta antisense gene.

doi:10.1080/01616412.1998.11740594

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Article

Prolonged survival of rats with intracranial C6 gliomas by treatment with TGF-beta antisense gene.

Neurological research - 1 Dec 1998

Liau L M, Fakhrai H, Black K L

Abstract excerpt

Using an intracranial rat C6 glioma model, we tested the hypothesis that gene modification of glioma cells to block the expression of the immunosuppressive cytokine TGF-beta (transforming growth factor beta) may enhance anti-tumor immune responses and thereby prolong survival of tumor-bearing ani...

Topics

Animals
Antisense Elements (Genetics)
Brain
Brain Neoplasms
Female
Genetic Therapy
Glioma
Necrosis
Phenotype
Polymerase Chain Reaction
Rats
Rats, Wistar
Survival Analysis
Transfection
Transforming Growth Factor beta
Treatment Outcome

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