Article
Characterization of human aortic smooth muscle cells expressing HPV16 E6 and E7 open reading frames.
The American journal of pathology - 1 Sept 1995
Conroy S C, Hart C E, Perez-Reyes N, Giachelli C M, Schwartz S M, McDougall J K
Abstract excerpt
A comparative study of human papillomavirus type 16 E6E7-transfected and normal human aortic smooth muscle cells by morphological, electron microscopic, immunofluorescent, and biochemical analyses demonstrated that the E6E7-expressing cells retained much of the phenotype of normal aortic smooth muscle cells, including expression of smooth muscle markers and appropriate growth responses to PDGF and heparin. These...
Topics
- Aorta
- Cells, Cultured
- Fetus
- Fluorescent Antibody Technique
- Gene Expression
- Heparin
- Humans
- Male
- Microscopy, Electron
- Middle Aged
- Muscle, Smooth, Vascular