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Article

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

1 Jan 1991

Abstract excerpt

The contribution of the E6 and E7 open reading frames of human papillomavirus type 6b (HPV6b) and HPV16 to immortalization of human keratinocytes was evaluated by using amphotropic recombinant retroviruses. The HPV16 E7 gene could immortalize primary human keratinocytes without the cooperation of the viral E6 gene; however, E6 was able to contribute significantly to the efficiency of the E7 immortalizing...

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PMID: 1845902
DOI: 10.1128/jvi.65.1.473-478.1991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cellsPMID 1845902Read ↗

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The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in cultureSemantic proximity Read ↗

The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes.Semantic proximity Read ↗

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