E5a gene of human papillomavirus type 11 is required for initiation but not for maintenance of transformation in NIH 3T3 cells.

doi:10.1099/0022-1317-75-8-1953

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Article

E5a gene of human papillomavirus type 11 is required for initiation but not for maintenance of transformation in NIH 3T3 cells.

The Journal of general virology - 1 Aug 1994

Chen S L, Tsao Y P, Lee J W, Liu H S, Yang C M, Tsao L T

Abstract excerpt

We have previously shown that the E5a gene of human papilloma virus type 11 (HPV-11/HPV-6c) is a transforming oncogene. In order to dissect the biological consequences of E5a gene expression we utilized the lac operator/repressor system to manipulate E5a gene expression. Cells were cotransfected...

Topics

3T3 Cells
Animals
Bacterial Proteins
Cell Transformation, Viral
Escherichia coli Proteins
Genes, Viral
Isopropyl Thiogalactoside
Lac Repressors
Mice
Oncogene Proteins, Viral
Oncogenes
Papillomaviridae
Phenotype
Proto-Oncogene Proteins c-jun
RNA, Messenger
Recombinant Proteins
Repressor Proteins
Transfection

Source

Open in PubMed

Identifiers

PMID: 8046397
DOI: 10.1099/0022-1317-75-8-1953

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8046397-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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