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Article

Enhanced detection of TP53 mutations using a GC-clamp in denaturing high performance liquid chromatography.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 2007

Greiner Timothy C

Abstract excerpt

Although denaturing gradient gel electrophoresis (DGGE) is a highly effective technique for screening for TP53 mutations, the use of denaturing high performance liquid chromatography (DHPLC) is a growing methodology. This report describes a comparison between DHPLC and DGGE in the detection of TP53 mutations in hematopoietic cell lines and lymphomas. In addition, the improved effectiveness of guanine cytosine...

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Share to Cell Line, Tumor
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 17471156
DOI: 10.1097/PDM.0b013e31802c29de

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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