Article
Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene.
Nature - 5 Sept 1991
Sakai T, Ohtani N, McGee T L, Robbins P D, Dryja T P
Abstract excerpt
The transcription of a eukaryotic gene is a consequence of intricate interactions between members of a set of transcription factors. We describe here evidence indicating that at least two distinct DNA-binding factors play an important part in the transcription of the human retinoblastoma gene (Rb...
Topics
- Activating Transcription Factors
- Base Sequence
- Binding Sites
- Blood Proteins
- Cell Line
- Cloning, Molecular
- DNA, Neoplasm
- Gene Expression
- Genes, Retinoblastoma
- Humans
- Molecular Sequence Data
- Mutation
- Pedigree
- Sp1 Transcription Factor
- Transcription Factors
- Transcription, Genetic
- Transfection