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Article

Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene.

Nature - 5 Sept 1991

Sakai T, Ohtani N, McGee T L, Robbins P D, Dryja T P

Abstract excerpt

The transcription of a eukaryotic gene is a consequence of intricate interactions between members of a set of transcription factors. We describe here evidence indicating that at least two distinct DNA-binding factors play an important part in the transcription of the human retinoblastoma gene (Rb). One of the factors reacts with a sequence overlapping with a potential Sp1 recognition sequence in the promoter...

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Identifiers

PMID: 1881452
DOI: 10.1038/353083a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene.PMID 1881452Read ↗

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