Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias.

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Article

Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias.

Leukemia - 1 May 1994

Corradini P, Inghirami G, Astolfi M, Ladetto M, Voena C, Ballerini P, Gu W, Nilsson K, Knowles D M, Boccadoro M

Abstract excerpt

The role of loss or inactivation of the retinoblastoma (Rb1) and p53 tumor suppressor genes in the pathogenesis of various human malignancies has been well established, yet little is known regarding plasma cell dyscrasias. In the present study, the loss of Rb1 protein expression, and the presence...

Topics

Base Sequence
Blotting, Southern
Gene Expression Regulation
Gene Expression Regulation, Leukemic
Gene Expression Regulation, Neoplastic
Gene Rearrangement
Genes, Retinoblastoma
Genes, p53
Genes, ras
Humans
Leukemia, Plasma Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Multiple Myeloma

Mutation

Paraproteinemias

Polymerase Chain Reaction

Prognosis

Source

Open in PubMed

Identifiers

PMID: 8182933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8182933-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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