Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p16 INK4a andp15INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance

1 Jul 2001

Abstract excerpt

p15(INK4b) and p16(INK4a) proteins are cell cycle regulators involved in the inhibition of G1 phase progression. High frequency of methylation of both genes has been reported in multiple myeloma (MM), but it remains to be determined how and when these alterations contribute to tumorigenesis. Monoclonal gammopathy of undetermined significance (MGUS) represents an early disease stage in a fraction of MMs. Plasma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation
Share to Hemoglobinopathies and Related Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11418489
DOI: 10.1182/blood.v98.1.244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p16 INK4a andp15INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significancePMID 11418489Read ↗

Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implicationsSemantic proximity Read ↗

DNA‐methylation analysis identifies the E‐cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathiesSemantic proximity Read ↗

Frequent Hypermethylation of p16 and p15 Genes in Multiple MyelomaSemantic proximity Read ↗

Detecting methylation patterns of <i>p16</i>, <i>MGMT</i>, <i>DAPK</i> and <i>E‐cadherin</i> genes in multiple myeloma patientsSemantic proximity Read ↗

Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survivalSemantic proximity Read ↗

DNA Methylation Analysis Determines the High Frequency of Genic Hypomethylation and Low Frequency of Hypermethylation Events in Plasma Cell TumorsSemantic proximity Read ↗

Monosomic Loss of MIR15A/MIR16-1 Is a Driver of Multiple Myeloma Proliferation and Disease ProgressionSemantic proximity Read ↗

Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias.Semantic proximity Read ↗

Possible roles for activating RAS mutations in the MGUS to MM transition and in the intramedullary to extramedullary transition in some plasma cell tumors.Semantic proximity Read ↗

ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance.Semantic proximity Read ↗

Genomic abnormalities in monoclonal gammopathy of undetermined significanceSemantic proximity Read ↗

Genomewide association study on monoclonal gammopathy of unknown significance (MGUS).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.