Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The significance of RB1 in multiple myeloma.

Frontiers in immunology - 1 Jan 2024

Wang Yiwen, Yang Rui, Liu Rui, Yang Ruoyu, Lin Zujie, He Aili

Abstract excerpt

The treatment of multiple myeloma (MM) has significantly advanced; however, the underlying genetic mechanisms remain elusive. Clonal events and genetic alterations are recognized as pivotal in the pathogenesis of MM. It is now understood that a multitude of gene mutations, including those affecting RAS, TP53, RB1, and 1q21 amplification, are prevalent in this disease. The incorporation of several high-risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Myeloma
Share to Mutation
Share to Retinoblastoma Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Retinoblastoma Protein

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 39664374
DOI: 10.3389/fimmu.2024.1415972
PMCID: PMC11631746

Genes

RB1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The significance of RB1 in multiple myeloma.PMID 39664374Read ↗

Role of 1q21 in Multiple Myeloma: From Pathogenesis to Possible Therapeutic TargetsSemantic proximity Read ↗

Clinical implications of cytogenetic and molecular aberrations in multiple myelomaSemantic proximity Read ↗

The Role of Epigenetics in the Development and Progression of Multiple MyelomaSemantic proximity Read ↗

Research Progress of Protein Arginine Methyltransferases (PRMTs) in Multiple Myeloma: From Molecular Mechanisms to Targeted TherapySemantic proximity Read ↗

Molecular pathogenesis of multiple myeloma and its premalignant precursorSemantic proximity Read ↗

International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple MyelomaSemantic proximity Read ↗

Multiple myeloma in the marrow: pathogenesis and treatments.Semantic proximity Read ↗

Therapeutic Potential of PRMT1 as a Critical Survival Dependency Target in Multiple MyelomaSemantic proximity Read ↗

Current Review on High-Risk Multiple Myeloma.Semantic proximity Read ↗

Deregulation and Targeting of TP53 Pathway in Multiple MyelomaSemantic proximity Read ↗

Epigenetic Aberrations in Multiple MyelomaSemantic proximity Read ↗

Notch signaling deregulation in multiple myeloma: A rational molecular target.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.