Article
The significance of RB1 in multiple myeloma.
Frontiers in immunology - 1 Jan 2024
Wang Yiwen, Yang Rui, Liu Rui, Yang Ruoyu, Lin Zujie, He Aili
Abstract excerpt
The treatment of multiple myeloma (MM) has significantly advanced; however, the underlying genetic mechanisms remain elusive. Clonal events and genetic alterations are recognized as pivotal in the pathogenesis of MM. It is now understood that a multitude of gene mutations, including those affecting RAS, TP53, RB1, and 1q21 amplification, are prevalent in this disease. The incorporation of several high-risk...
Topics
- Humans
- Multiple Myeloma
- Retinoblastoma Binding Proteins
- Animals
- Retinoblastoma Protein
- Mutation
- Ubiquitin-Protein Ligases