Article
Loss of p53 exacerbates multiple myeloma phenotype by facilitating the reprogramming of hematopoietic stem/progenitor cells to malignant plasma cells by MafB.
Cell cycle (Georgetown, Tex.) - 15 Oct 2012
Vicente-Dueñas Carolina, González-Herrero Inés, García Cenador María Begoña, García Criado Francisco Javier, Sánchez-García Isidro
Abstract excerpt
Multiple myeloma (MM) is a serious, mostly incurable human cancer of malignant plasma cells. Chromosomal translocations affecting MAFB are present in a significant percentage of multiple myeloma patients. Genetically engineered Sca1-MafB mice, in which MafB expression is limited to hematopoietic stem/progenitor cells (HS/P-Cs), display the phenotypic features of MM. Contrary to many other types of cancer, it is...
Topics
- Animals
- Antigens, Ly
- Cell Transformation, Neoplastic
- Gene Deletion
- Hematopoietic Stem Cells
- Hemizygote
- Homozygote
- Humans
- MafB Transcription Factor
- Membrane Proteins
- Mice
- Mice, Transgenic
- Multiple Myeloma