Article
SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast.
The EMBO journal - 9 Feb 2005
Harrison Clare, Katayama Satoshi, Dhut Susheela, Chen Dongrong, Jones Nic, Bähler Jürg, Toda Takashi
Abstract excerpt
Ubiquitin-dependent proteolysis regulates gene expression in many eukaryotic systems. Pof1 is an essential fission yeast F-box protein that is homologous to budding yeast Met30. Temperature-sensitive pof1 mutants display acute growth arrest with small cell size. Extragenic suppressor analysis identified Zip1, a bZIP (basic leucine zipper) transcription factor, as a target for Pof1. We show Zip1 is stabilized in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
