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Article

Thioredoxin deficiency causes the constitutive activation of Yap1, an AP-1-like transcription factor in Saccharomyces cerevisiae.

The Journal of biological chemistry - 1 Oct 1999

Izawa S, Maeda K, Sugiyama K, Mano J, Inoue Y, Kimura A

Abstract excerpt

Yap1 is a transcription factor that responds to oxidative stress in Saccharomyces cerevisiae. The activity of Yap1 is regulated at the level of its intracellular localization, and a cysteine-rich domain at the C terminus of Yap1 is involved in this regulation. We investigated the effects of redox-regulatory proteins, thioredoxin and glutaredoxin, on the regulation of Yap1, using the deficient mutants of these...

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Identifiers

PMID: 10497208
DOI: 10.1074/jbc.274.40.28459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Thioredoxin deficiency causes the constitutive activation of Yap1, an AP-1-like transcription factor in Saccharomyces cerevisiae.PMID 10497208Read ↗

Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Nuclear import of the yeast AP-1-like transcription factor Yap1p is mediated by transport receptor Pse1p, and this import step is not affected by oxidative stress.Semantic proximity Read ↗

Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae.Semantic proximity Read ↗

The thioredoxin system protects ribosomes against stress-induced aggregation.Semantic proximity Read ↗

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Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity.Semantic proximity Read ↗

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