Article
Overexpression of the SNQ3/YAP1 gene confers hyper-resistance to nitrosoguanidine in Saccharomyces cerevisiae via a glutathione-independent mechanism.
Current genetics - 1 May 1994
Grey M, Brendel M
Abstract excerpt
The MNNG hyper-resistance of yeast transformants containing multiple copies of the SNQ3/YAP1 yeast gene is not caused by lowered MNNG activation due to depleted pools of glutathione. On the contrary, the SNQ3/YAP1-encoded protein stimulates production of GSH, apparently by promoter activation due to the AP-1 recognition element. Expression of at least one further gene, encoding a protein with a strong detoxifying...
Topics
- Base Sequence
- DNA Repair
- DNA, Fungal
- Drug Resistance, Microbial
- Gene Expression
- Genes, Fungal
- Glutathione
- Methylnitronitrosoguanidine
- Molecular Sequence Data
- Phenotype
- Saccharomyces cerevisiae