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Article

Inhibition of Yap2 activity by MAPKAP kinase Rck1 affects yeast tolerance to cadmium.

FEBS letters - 14 Sept 2015

Mazzola Daiane, Pimentel Catarina, Caetano Soraia, Amaral Catarina, Menezes Regina, Santos Claudia N, Eleutherio Elis, Rodrigues-Pousada Claudina

Abstract excerpt

Yap2 is a cadmium responsive transcription factor that interacts with MAPK-activated protein (MAPKAP) kinase Rck1. We show that Rck1 deletion confers protection against cadmium toxicity and that the mechanism underlying this observation relies on Yap2. Rck1 removal from the yeast genome potentiates Yap2 activity by increasing protein half-life and delaying its nuclear export. As a consequence, several Yap2...

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Identifiers

PMID: 26296316
DOI: 10.1016/j.febslet.2015.07.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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