Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia.

doi:10.1016/s0145-2126(97)80032-x

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Article

Exon 5 mutations in the p53 gene in relapsed childhood acute lymphoblastic leukemia.

Leukemia research - 1 Aug 1997

Blau O, Avigad S, Stark B, Kodman Y, Luria D, Cohen I J, Zaizov R

Abstract excerpt

Thirty seven children with relapsed acute lymphoblastic leukemia (ALL), 25 B-lineage and 12 T-lineage, were analyzed for p53 alterations at different stages of the disease. Loss of heterozygosity (LOH) was detected in the relapse phase in three patients. p53 mutations were identified by single st...

Topics

Adolescent
Child
Child, Preschool
Disease Progression
Exons
Female
Genes, p53
Humans
Loss of Heterozygosity
Male
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence
Sequence Analysis, DNA

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