Article
Cytotoxic T lymphocytes specific for HIV-1 gp160 antigen and synthetic P18IIIB peptide in an HLA-A11-immunized individual.
AIDS research and human retroviruses - 1 Jan 1994
Achour A, Lemhammedi S, Picard O, M'Bika J P, Zagury J F, Moukrim Z, Willer A, Beix F, Burny A, Zagury D
Abstract excerpt
Cytotoxic T cell determinants should be an important component of an anti-human immunodeficiency virus (HIV) vaccine. The epitopes of proteins can be defined with short synthetic peptides for class I-restricted CTLs. An immunodominant CTL epitope from the HIV-1 IIIB envelope protein gp160 comprising 15 amino acids (residues 315-329: RIQRGPGRAFVTIGK) (P18IIIB) has been identified that is recognized by class I MHC...
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