Article
The emerging picture of p53.
The International journal of biochemistry - 1 Feb 1994
Selter H, Montenarh M
Abstract excerpt
1. The cellular phosphoprotein p53 is a negative regulator of the cell growth. A great majority of human malignancies expresses a mutated p53 that represents an oncogenic version of the protein. 2. However, in the meantime many tumors were identified containing a p53 protein without any mutation. Here also other events than genomic alterations of p53 might be implicated in the process of cell transformation. 3....
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