Article
The rat bladder tumor model system RBT resembles phenotypically and cytogenetically human superficial transitional cell carcinoma.
Urological research - 1 Jan 1993
van Moorselaar R J, Ichikawa T, Schaafsma H E, Jap P H, Isaacs J T, van Stratum P, Ramaekers F C, Debruyne F M, Schalken J A
Abstract excerpt
A cohort of 300 ACI rats was kept under standard laboratory conditions. After 30 months or upon natural death, complete autopsy was performed. In the genitourinary tract four kidney and five bladder tumors were found. Two of these bladder tumors, RBT323 and RBT157, are serially transplantable. In the fifth transplant generation the RBT323 tumor becomes metastatic to the lungs in more than 90% of animals. The...
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