Insulin stimulates colony formation at a nonpermissive temperature by thermosensitive mutants of Chinese hamster lung cells that exhibit anchorage-independent growth in soft-agar culture.

Abstract excerpt

The effects of various growth factors on the colony-forming ability were examined in soft-agar culture of thermosensitive (ts) mutants derived from Chinese hamster lung cells that exhibited anchorage-independent growth. Fibroblast growth factor (FGF), a competence factor, and epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I), progression factors, did not stimulate colony formation in...

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