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Article

Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2.

Molecular and cellular biology - 1 Dec 1992

Wek R C, Cannon J F, Dever T E, Hinnebusch A G

Abstract excerpt

GCN2 is a protein kinase in Saccharomyces cerevisiae that is required for increased expression of the transcriptional activator GCN4 in amino acid-starved cells. GCN2 stimulates GCN4 synthesis at the translational level by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2). We identified a truncated form of the GLC7 gene, encoding the catalytic subunit of a type 1 protein...

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Identifiers

PMID: 1333044
DOI: 10.1128/mcb.12.12.5700-5710.1992
PMCID: PMC360510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2.PMID 1333044Read ↗

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.Semantic proximity Read ↗

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Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.Semantic proximity Read ↗

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Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.Semantic proximity Read ↗

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GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast.Semantic proximity Read ↗

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.Semantic proximity Read ↗

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