Article
Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2.
Molecular and cellular biology - 1 Dec 1992
Wek R C, Cannon J F, Dever T E, Hinnebusch A G
Abstract excerpt
GCN2 is a protein kinase in Saccharomyces cerevisiae that is required for increased expression of the transcriptional activator GCN4 in amino acid-starved cells. GCN2 stimulates GCN4 synthesis at the translational level by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2). We identified a truncated form of the GLC7 gene, encoding the catalytic subunit of a type 1 protein...
Topics
- Alleles
- Gene Expression Regulation, Fungal
- Genetic Complementation Test
- Histidine
- Phosphoprotein Phosphatases
- Phosphorylation
- Plasmids
- Protein Biosynthesis
- Protein Kinases
- Protein Serine-Threonine Kinases