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Article

Two modes of germline instability at human minisatellite MS1 (locus D1S7): complex rearrangements and paradoxical hyperdeletion.

American journal of human genetics - 1 Jun 2003

Berg Ingrid, Neumann Rita, Cederberg Håkan, Rannug Ulf, Jeffreys Alec J

Abstract excerpt

Minisatellite MS1 (locus D1S7) is one of the most unstable minisatellites identified in humans. It is unusual in having a short repeat unit of 9 bp and in showing somatic instability in colorectal carcinomas, suggesting that mitotic replication or repair errors may contribute to repeat-DNA mutation. We have therefore used single-molecule polymerase chain reaction to characterize mutation events in sperm and...

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Identifiers

PMID: 12748906
DOI: 10.1086/375629
PMCID: PMC1180304

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