Article
Minisatellite mutation rate variation associated with a flanking DNA sequence polymorphism.
Nature genetics - 1 Oct 1994
Monckton D G, Neumann R, Guram T, Fretwell N, Tamaki K, MacLeod A, Jeffreys A J
Abstract excerpt
Human minisatellite mutation in the male germline frequently involves complex interallelic gene conversion events restricted to one end of the tandem repeat array. Some alleles at minisatellite MS32 show reduced variability in human populations and are associated with a G to C transversion upstream of the array. Analysis of single sperm demonstrated a frequently profound reduction in mutation rate at alleles...
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