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Article

Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content.

Journal of neurochemistry - 1 Aug 2007

Hamid Runa, Kilger Ellen, Willem Michael, Vassallo Neville, Kostka Markus, Bornhövd Carsten, Reichert Andreas S, Kretzschmar Hans A, Haass Christian, Herms Jochen

Abstract excerpt

Consecutive cleavages of amyloid precursor protein (APP) generate APP intracellular domain (AICD). Its cellular function is still unclear. In this study, we investigated the functional role of AICD in cellular Ca(2+) homeostasis. We could confirm previous observations that endoplasmic reticulum Ca(2+) stores contain less calcium in cells with reduced APP gamma-secretase cleavage products, increased AICD...

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Source

Identifiers

PMID: 17763532
DOI: 10.1111/j.1471-4159.2007.04627.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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