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Article

Glutamate, beta-amyloid precursor proteins, and calcium mediated neurofibrillary degeneration.

Journal of neural transmission. Supplementum - 1 Jan 1994

Smith-Swintosky V L, Mattson M P

Abstract excerpt

In this article we present evidence supporting the interaction between excitotoxicity, beta APP mismetabolism, metabolic compromise and intracellular calcium destabilization in the process of neurodegeneration associated with Alzheimer's disease (AD). AD is characterized by the presence of neurof...

Topics

Alzheimer Disease
Amyloid beta-Protein Precursor
Animals
Calcium
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 21
Glutamic Acid
Humans
Models, Neurological
Mutation
Nerve Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurofibrillary Tangles

Rats

Source

Identifiers

PMID: 7897398
DOI: 10.1007/978-3-7091-9350-1_3

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7897398-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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