Article
beta-Amyloid precursor protein mismetabolism and loss of calcium homeostasis in Alzheimer's disease.
Annals of the New York Academy of Sciences - 24 Sept 1993
Barger S W, Smith-Swintosky V L, Rydel R E, Mattson M P
Abstract excerpt
The suspected involvement of the beta-amyloid precursor protein (beta APP) in the etiology of Alzheimer's disease (AD) has been strengthened by recent genetic evidence, but pursuit of the mechanisms involved will initially require basic cell biology approaches. Several studies have concentrated on toxic activities of beta-amyloid peptide (beta AP) itself, illuminating its contributions to excitotoxicity and...
Topics
- Aging
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Calcium
- Homeostasis
- Humans
- Models, Biological
- Mutation
- Protein Processing, Post-Translational