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Article

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.

Science (New York, N.Y.) - 2 Jun 1995

Koch W J, Rockman H A, Samama P, Hamilton R A, Bond R A, Milano C A, Lefkowitz R J

Abstract excerpt

Transgenic mice were created with cardiac-specific overexpression of the beta-adrenergic receptor kinase-1 (beta ARK1) or a beta ARK inhibitor. Animals overexpressing beta ARK1 demonstrated attenuation of isoproterenol-stimulated left ventricular contractility in vivo, dampening of myocardial adenylyl cyclase activity, and reduced functional coupling of beta-adrenergic receptors. Conversely, mice expressing the...

Topics

Adenylyl Cyclases
Animals
Blood Pressure
Cyclic AMP-Dependent Protein Kinases
GTP-Binding Proteins
Heart
Isoproterenol
Mice
Mice, Transgenic
Myocardial Contraction
Myocardium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Receptors, Adrenergic, beta

Sarcolemma

Ventricular Pressure

beta-Adrenergic Receptor Kinases

Source

Identifiers

PMID: 7761854
DOI: 10.1126/science.7761854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7761854-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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