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Article

Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis.

Neurology - 12 Oct 1999

Fernandez-Arquero M, Arroyo R, Rubio A, Martin C, Vigil P, Conejero L, Figueredo M A, de la Concha E G

Abstract excerpt

The associations of three promoter polymorphisms in the tumor necrosis factor (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant correlation was found between MS susceptibility and the TNFA-376 polymorphism. This association was independent of the human leukocyte antigen (HLA) class II association and the combined inheritance of HLA-DRB1*1501 and the TNFA-376A allele more than...

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Source

Identifiers

PMID: 10522904
DOI: 10.1212/wnl.53.6.1361

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis.PMID 10522904Read ↗

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The polymorphisms of the TNF-α gene in multiple sclerosis?--a meta-analysis.Semantic proximity Read ↗

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Association of a tumor necrosis factor alpha polymorphism with MS susceptibility.Semantic proximity Read ↗

Susceptibility to multiple sclerosis mediated by HLA-DRB1 is influenced by a second gene telomeric of the TNF cluster.Semantic proximity Read ↗

Interaction of HLA-DRB1*1501 allele and TNF-alpha -308 G/A single nucleotide polymorphism in the susceptibility to multiple sclerosis.Semantic proximity Read ↗

TNF-alpha polymorphisms in multiple sclerosis: no association with -238 and -308 promoter alleles, but the microsatellite allele a11 is associated with the disease in French patients.Semantic proximity Read ↗

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TNF-alpha promoter polymorphisms in multiple sclerosis: no association with -308 and -238 alleles, but the -857 alleles in associated with the disease in Turkish patients.Semantic proximity Read ↗

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