Article
crumbs and stardust, two genes of Drosophila required for the development of epithelial cell polarity.
Development (Cambridge, England). Supplement - 1 Jan 1993
Knust E, Tepass U, Wodarz A
Abstract excerpt
Loss-of-function mutations in the Drosophila genes crumbs and stardust are embryonic lethal and cause a breakdown of ectodermally derived epithelia during organogenesis, leading to formation of irregular cell clusters and extensive cell death in some epithelia. The mutant phenotype develops gradu...
Topics
- Animals
- Cell Polarity
- Cytoplasm
- Drosophila
- Drosophila Proteins
- Epithelium
- Gene Expression
- Genes, Insect
- Membrane Proteins
- Mutation
- Phenotype
- Signal Transduction