Article
crumbs and stardust, two genes of Drosophila required for the development of epithelial cell polarity.
Development (Cambridge, England). Supplement - 1 Jan 1993
Knust E, Tepass U, Wodarz A
Abstract excerpt
Loss-of-function mutations in the Drosophila genes crumbs and stardust are embryonic lethal and cause a breakdown of ectodermally derived epithelia during organogenesis, leading to formation of irregular cell clusters and extensive cell death in some epithelia. The mutant phenotype develops gradually and affects the various epithelia to different extents. crumbs encodes a large transmembrane protein with 30...
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