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Article

Dynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity.

The Journal of cell biology - 14 Jan 2008

Li Zhouhua, Wang Liwei, Hays Thomas S, Cai Yu

Abstract excerpt

Asymmetrical localization of transcripts coupled with localized translation constitutes an important mechanism widely deployed to regulate gene activity in a spatial manner. The conserved transmembrane protein Crumbs (Crb) is an important regulator of epithelial polarity. However, it remains uncl...

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Share to Cell Polarity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18195099
DOI: 10.1083/jcb.200707007
PMCID: PMC2213619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18195099-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity.PMID 18195099Read ↗

Dynein regulates epithelial polarity and the apical localization of stardust A mRNA.Semantic proximity Read ↗

Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs.Semantic proximity Read ↗

CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.Semantic proximity Read ↗

Role of kinesin heavy chain in Crumbs localization along the rhabdomere elongation in Drosophila photoreceptor.Semantic proximity Read ↗

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.Semantic proximity Read ↗

CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila.Semantic proximity Read ↗

Identification of genes required for apical protein trafficking in Drosophila photoreceptor cellsSemantic proximity Read ↗

Redundant RNA recognition events in bicoid mRNA localization.Semantic proximity Read ↗

Changes in bicoid mRNA anchoring highlight conserved mechanisms during the oocyte-to-embryo transition.Semantic proximity Read ↗

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.Semantic proximity Read ↗

Anisotropic Crb accumulation, modulated by Src42A, orients epithelial tube growth in <i>Drosophila</i>Semantic proximity Read ↗

Crumbs is required to achieve proper organ size control during Drosophila head development.Semantic proximity Read ↗

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