Article
Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1994
Tzukerman M T, Esty A, Santiso-Mere D, Danielian P, Parker M G, Stein R B, Pike J W, McDonnell D P
Abstract excerpt
We have used a series of human estrogen receptor (ER) mutants to evaluate the cell- and promoter-specific transcriptional activities of the TAF1 and TAF2 transactivation regions within the human ER. We show that the manifestation of TAF1 or TAF2 function depends strongly upon promoter context; on certain promoters, both the TAF1 and TAF2 activators are required for wild-type transcriptional activity, whereas on...
Topics
- Binding, Competitive
- Cell Line
- Complement C3
- Humans
- Mutation
- Promoter Regions, Genetic
- Receptors, Estrogen
- Recombinant Proteins
- Tamoxifen
- Transcription, Genetic